Pathways of complement activation in glomerulonephritis

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Classical complement pathway activation in membranoproliferative glomerulonephritis.

Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...

متن کامل

Complement and glomerulonephritis: new insights.

PURPOSE OF REVIEW The last few years have seen a huge increase in our understanding of the role of the complement system and its regulation in glomerular disease. Our aim is to summarize the most important advances in this field. RECENT FINDINGS The role of complement in systemic lupus erythematosus continues to be elucidated. Classical pathway components protect from the development of autoi...

متن کامل

Normal complement in early poststreptococcal glomerulonephritis.

Patients with acute poststreptococcal glomerulonephritis are usually found to have reduced serum concentrations of the third component of complement (C3), properdin, and total haemolytic complement (CH50).' We report here a unique variation of this pattern. A previously healthy 72-year-old boy was admitted to hospital after one day of macroscopic haematuria. Blood pressure was 110/80 mm Hg. Uri...

متن کامل

Glomerular complement components in human glomerulonephritis.

154 of 255 individual human renal biopsies studied by immunofluorescence contained varying combinations of immunoglobulins (Ig), complement (C) components C1q, C3, C4, C5, C6, C8, C3 proactivator (C3PA), and/or properdin. 10 patients had linear deposits of Ig in glomeruli characteristic of antiglomerular basement membrane (GBM) antibodies; nine patients had C3 deposits (minimal in three) with g...

متن کامل

Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis

Immunopathological evidence suggests that activation of the alternative pathway of complement (AP) is involved in membranoproliferative glomerulonephritis (MPGN) and in immunoglobulin A nephropathy. In this report we describe an AP dysfunction-associated factor that was isolated from the serum and urine of a patient with hypocomplementemic MPGN. Extensive glomerular deposits of C3, properdin, a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Kidney International

سال: 1972

ISSN: 0085-2538

DOI: 10.1038/ki.1972.14